{Author}: Chen Ming-Hong;Lian Yun-Yang;Fang Dong-Sheng;Chen Li;Jia Jia;Zhang Wen-Long;Lin Ru;Xie Yang;Bi Hong-Kai;Jiang Hong*

{Journal}: Natural product research

{Year}: 2019

{Pages}: 1-7

{Keywords}:Actinomycete;Helicobacterpylori;Verrucosispora;Antibiotics;Antimicrobial activity

{Abstract}: The actinomycete strain FIM06-0036 was isolated from marine sponge sample collected from the East China Sea and identified as Verrucosispora sp. based upon the results of 16S rRNA sequence analysis. One new alkaloid, 2-ethylhexyl 1H-imidazole-4-carboxylate ( 1 ), together with a known alkaloid butyl 1H-imidazole-4-carboxylate ( 2 ) was obtained from the fermentation products of this strain, the structures of compounds 1 and 2 were determined by their detailed analysis of 1 D, 2 D NMR and HR-ESI-MS data, along with literature data analysis. Compounds 1 and 2 were evaluated for their antimicrobial activity with MIC (minimum inhibitory concentration) values ranging from 8 to 256 μg · mL-1 against Helicobacter pylori, Klebsiella Pneumonia, Staphylococcus aureus and Enterococcus faecalis.