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41-Azido-41-deoxyrapamycin
{Author}: Lijun Xie, Jie Huang, Jian Zuo, Hui Yu and Yuanrong Cheng*
{Journal}: Acta Crystallographica
{Year}: 2012
{Volume}:68
{Issue}:4
{Pages}: o1206-o1207
{Abstract}:The title compound, C51H78N4O12, is a derivative of rapamycin, a triene macrolide antibiotic molecule isolated from Streptomyces hygroscopicus. The macrocyclic ring structure has 15 chiral centres, with one of the substituent hydroxy groups giving an intramolecular hydrogen bond to a ketone O-atom acceptor. The molecules also form intermolecular hydroxy-ketone O-HO hydrogen-bonding associations, giving one-dimensional chains extending along (010). The crystal has 108 Å3 solvent-accessible voids.